JMJD6 and colonic neoplasm: Similarly, MS analyses indicated that immunoprecipitated Jmjd6 undergoes self-hydroxylation on K167 in HeLa cells (Webby, 2012) and JMJD6 lysyl-hydroxylates endogenous p53 on position K382 in HCT116 colon cancer cells (Wang et al., 2014) (as discussed below).