Interestingly, B cells from B-cell chronic lymphocytic leukemia (63) or non-Hodgkin’s lymphoma (64), as well as B cells from patients with autoimmune disorders, namely rheumatoid arthritis (65), systemic lupus erythematosus (66), and primary Sjogren’s syndrome (67) also express BAFF, which rescues them from apoptosis in an autocrine loop. The gene discussed is TNFSF13B; the disease is B-cell chronic lymphocytic leukemia.