CD226 and neoplasm: However, in prostate cancer, lower expression of some activating receptors (NKp46, NKp30, NKG2D, DNAM-1, CD16) and higher expression of the inhibitory receptor ILT2 were observed, with more pronounced effects in NK cells infiltrating metastatic than localized tumors; these latter data indicate that tumor microenvironment can impair NK cytotoxic functions by altering the balance between NK activating and inhibitory receptors.