Basal IL-8 levels obtained in this study were neither comparable to levels found in crevicular fluid of patients with periodontitis (over 90,000-fold higher), nor to levels obtained by stimulated salivary measurement (250 pg/ml) in healthy individuals, which is to be expected due to impaired oral health and different sampling method as compared to our study (Navazesh and Christensen, 1982; Goutoudi et al., 2012). This evidence concerns the gene CXCL8 and periodontitis.