The miRNA repertoire of colon cancer cell EVs is profoundly affected by mutations in the transcription factor KRAS. Cha et al. profiled the transcriptome of EVs released by cell lines differing only in KRAS status and showed that levels of the pro-metastatic miR-100 are decreased in mutant KRAS EVs, whereas miR-10b abundance is increased in these samples (Cha et al., 2015). The gene discussed is KRAS; the disease is malignant colon neoplasm.