CBS and cardiac hypertrophy: Furthermore, our previous studies demonstrated that down-regulation of renal H2S/CBS pathway induced by high salt led to the development of hypertension, and H2S could improve aortic structural remodeling and reduce the high salt-induced renal injury in Dahl rats (Huang et al., 2015, 2016), suggesting that the effect of H2S on the function and structure of aorta and kidney participated in the protective regulation of H2S on the myocardial hypertrophy.