Similar to histone-modifying enzymes, several natural compounds such as polyphenols, flavonoids and antraquinones (e.g., (-)-epigallocatechin-3-gallate and laccaic acid A) inhibit DNMT activity and/or expression, resulting in the re-expression of anti-proliferation/tumor suppressor genes, tumor growth inhibition and cell death (Lee et al., 2006a). Here, DNMT1 is linked to neoplasm.