APP and Alzheimer disease: In addition to cholinergic loss and hippocampal-dependent memory deficits, the activation of amyloidogenic APP cascade with intra/extracellular accumulation of Aβ peptide(s) along with the dysmetabolism (hyperphosphorylation/cleavage) of tau are also detected in animal and cellular neuronal models undergoing NGF withdrawal which recapitulate a comprehensive AD-like neuropathology (Capsoni et al., 2000; Ruberti et al., 2000; Matrone et al., 2008a,b; Houeland et al., 2010; Amadoro et al., 2011; Triaca et al., 2016).