MAPT and Alzheimer disease: Finally, phenotypic knockout of NGF via its antibody-mediated neutralization in adult transgenic AD11 mice causes age-dependent neurodegenerative changes which are reminiscent of human AD pathology characterized by severe deficits in basal forebrain cholinergic neurons, classic histopathological hallmarks including amyloid plaques and tau neurofibrillary tangles in cortical and hippocampal neurons, behavioral deficits (Capsoni et al., 2000).