APP and Alzheimer disease: NGF deficits are proved to be correlated both to amyloidogenic APP processing (Capsoni et al., 2002; Matrone et al., 2009) and to synaptic impairment (Lagostena et al., 2010) in cellular and animal AD models, further supporting the “neurotrophic unbalance” hypothesis as underlying trigger of AD-like neurodegeneration (Francis et al., 1999; Cattaneo and Calissano, 2012).