Besides, the work we have presented is also consistent with compelling evidence showing that the changes in synaptic structure and function are early markers of age-linked AD (Terry et al., 1991; Selkoe, 2002; Scheff et al., 2006, 2007; Nimmrich and Ebert, 2009) and that the levels of NGF are significantly decreased in the cholinergic basal forebrain of AD brains (Mufson et al., 1995). This evidence concerns the gene NGF and Alzheimer disease.