NGF and Alzheimer disease: Furthermore, our findings on the coordinate NGF-dependent regulation of selected presynaptic proteins involved in vesicles trafficking and of neurontransmitter exocytosis are supported by previous studies reporting that the application of either NGF or TrkA NGF-mimetic agonists successfully rescues the loss of cortical cholinergic boutons in impaired old rats (Cuello et al., 2007), in AD mice models (Aboulkassim et al., 2011; Capsoni et al., 2012) and in humans (Tuszynski et al., 2005; Rafii et al., 2014).