An imbalance between the TrkA-mediated survival signaling and the p75NTR-mediated pro-apoptotic signaling has been hypothesized to compromise the cholinergic basal forebrain neuronal function(s) during the prodromal stages of AD (Counts and Mufson, 2005; Mesulam, 2013). The gene discussed is NGFR; the disease is Alzheimer disease.