Of note, APP has three putative Tyr phosphorylation sites on the C-terminal domain (Tyr653, Tyr682, and Tyr687; Oishi et al., 1997) and despite our previous evidence pointing to the Tyr682 residue as the crucial player in APP signaling (Matrone, 2013), we cannot exclude the possibility that also other Tyr(s) on the APP sequence are phosphorylated in AD patients. The gene discussed is APP; the disease is Alzheimer disease.