Recently N-(2-carboxyacetyl)-D-valine-methyl ester, also known as ZLc-002-1, a valine-based analog of the C-terminus of NOS1AP (Figure 3A), has been proposed as a competitive inhibitor for nNOS PDZ pocket ligands and has shown efficacy against anxiety induced by chronic mild stress (Zhu et al., 2014). Here, NOS1 is linked to Anxiety.