ITM2B and dementia: Mutant forms of ITM2B, encoding the BRICHOS (see below) domain containing Bri2 protein are etiologic in Familial British Dementia and Familial Danish Dementia, while mutations in the gene (SFTPC) encoding another protein with a BRICHOS domain, lung surfactant C precursor (proSP-C), cause interstitial lung disease (ILD) with pulmonary amyloid deposits.