The proteins containing a BRICHOS domain have a wide range of functions, and disease associations, including ILD with amyloid deposits (proSP-C), dementia (Bri2), and cancer (Chondromodulin-I) (Sánchez-Pulido et al., 2002; Willander et al., 2012a). The gene discussed is ITM2B; the disease is interstitial lung disease.