Mutations in Bri2 give rise to release of extended, 34-residue, C-terminal peptides, ABri, or ADan, that deposit primarily in the CNS in two rare amyloid diseases, familial British dementia (FBD) and familial Danish dementia (FDD), respectively (Cantlon et al., 2015a). This evidence concerns the gene ITM2B and ADan amyloidosis.