Data from FBD-Bri2 and FDD-Bri2 knock-in mice as well as human patients show a reduction in Bri2 levels (Tamayev et al., 2010a; Matsuda et al., 2011), and knocking in Bri2 in FDD-Bri2 knock-in mice rescues negative effects on cognition (Tamayev et al., 2010a,b). This evidence concerns the gene ITM2B and ADan amyloidosis.