We will discuss the available information describing the biologic and biophysical findings that are apparently involved in the prevention of one form of amyloid, i.e., that formed by the Aβ protein seen in the plaques in human AD, by BRICHOS and TTR, molecules that are direct precursors of other distinct forms of human amyloidosis and what this may mean in the universe of protein-protein interactions in complex organisms. Here, TTR is linked to Alzheimer disease.