The best features, i.e. six biomarkers (adiponectin, C-reactive protein, ferritin, interleukin-2 receptor A, glucose, and insulin), were used in a PreDx diabetes risk score (DRS) model providing an AUC of 0.76 that increased to 0.78 when family history, age, BMI, and waist circumference were added. The gene discussed is INS; the disease is diabetes mellitus.