Although our initial intention was to identify a single biomarker, statistical evaluation of the data revealed a promising features selection matrix using three glycation sites in HSA (K93, K262, and K414) besides HP K141 representing short-to-medium term glucose fluctuations in combination with twelve routine parameters typically used to characterize T2DM (FPG, HbA1c, fasting insulin), metabolic syndrome (triglycerides and blood pressure), obesity (BMI, waist circumference, waist-to-hip ratio), inflammation (leukocytes, C-reactive protein), and insulin resistance (HOMA-IR), and age [33]. This evidence concerns the gene INS and type 2 diabetes mellitus.