This concept is supported by recent studies reporting that increased levels of plasminogen activator inhibitor 1 (PAI-1), thrombin activatable fibrinolysis inhibitor (TAFI) or tissue factor pathway inhibitor (TFPI), which are synthesized and secreted by activated endothelial cells are related with infertility and IVF failure [29–32]. The gene discussed is CPB2; the disease is Infertility.