MAPT and Alzheimer disease: The anomalous pattern of events initiated in the AD brain suggests that once amyloid and tau pathologies start, neighbouring neuronal cells also be affected by synaptotoxicity of Aβ oligomers (Ferreira et al., 2015; García-Arencibia et al., 2010; Santa-Maria et al., 2012; Wang and Mandelkow, 2012).