CFL1 and Alzheimer disease: Whilst β-amyloid (Aβ) plaques, some small and soluble oligomeric species of Aβ-like Aβ-derived diffusible ligands (ADDLs) (Haass and Selkoe, 2007; Klein et al., 2001; Townsend et al., 2006; Walsh et al., 2002) and neurofibrillary tangles (NFTs) remain the primary protagonists in AD, there has been growing interest in understanding the changes in the total cytoskeletal network through reorganization, sometimes grouped or referred to as cofilin pathologies (Bamburg and Bloom, 2009).