Under AD conditions, Grb2 expression showed significant (**P=0.0002) upregulation compared to WT, and cytoskeletal proteins showed significant (**P=0.0003 α-tubulin; **P=0.001 vimentin; *P=0.013 α-SMA and *P=0.0192 stathmin1) downregulation. This evidence concerns the gene GRB2 and Alzheimer disease.