Consistently, various means of interfering with obesity-related adipose tissue changes, including inhibition of inflammatory cascades and the stress-related MAP kinase JNK, resulted in decreased hepatic steatosis, insulin resistance and glucose overproduction (Sabio et al. 2008, Wueest et al. 2010, Zhang et al. 2011). Here, MAPK8 is linked to obesity due to melanocortin 4 receptor deficiency.