Indeed, comparing changes in the adipocytokine profile of HFF→NC vs HFF to the effect of combined pharmacological inhibition of adipose tissue JNK and p38 MAP kinase suggests the following pathway: obesity reversal rapidly normalizes p38 MAPK and JNK hyperactivation, resulting in changes in adipocytokine secretion from adipose tissue (including increases in adiponectin and IL-10 and decreased secretion of DPP4 and IL-6). This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.