This inflammatory response clearly occurred before the development of obesity (Elgazar-Carmon et al. 2008, Talukdar et al. 2012), but already could be tied to insulin resistance, particularly in the liver (Elgazar-Carmon et al. 2008, Hadad et al. 2013). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.