CXCL8 and systemic inflammatory response syndrome: Once initiated, the SIRS is maintained by a number of proinflammatory mediators including interleukin-1 (IL-1), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) [4].