IGF1R and neoplasm: Apoptosis was regulated through the action of various genes including baculoviral IAP repeat containing 3 (BIRC3) encoding for an inhibitor of apoptosis protein acting on killing tumor cells; death-associated protein kinase 2 (DAPK2) whose overexpression was shown to induce cell apoptosis; Retinoblastoma-Like 1 (RBL1) encoding for a tumor suppressor protein involved in cell cycle regulation; insulin-like growth factor 1 receptor (IGF1R) encoding for a growth factor with tyrosine kinase activity, having an anti-apoptotic effect and being highly overexpressed in most malignant tissues [31].