Based on the above results, we analyzed the effect of IQS019 on the phosphorylation status of Syk, Lyn and Btk in four cell lines representative of MCL (UPN-1), FL (DOHH-2), CLL (JVM-13), and DLBCL (OCI-LY10) subtypes. This evidence concerns the gene BTK and B-cell chronic lymphocytic leukemia.