Remarkably, a dose of IQS019 as low as 1 μM was sufficient to completely counteract the anti-IgM-mediated activation of Syk and Lyn in the highly IgM-responsive (unmutated IGHV) CLL sample showing the greatest efficacy of the stimulation (CLL#10, Fig. 3a). The gene discussed is SYK; the disease is B-cell chronic lymphocytic leukemia.