It was recently shown that facilitating T-cell infiltration into the tumor microenvironment, by targeting the tumor necrosis factor superfamily member LIGHT (also known as TNFSF14, tumor necrosis factor superfamily member 14), can overcome resistance to PD-L1 blockade therapy in a xenograft mouse model of colon cancer and fibrosarcoma [112]. This evidence concerns the gene TNFSF14 and colonic neoplasm.