11 ADOA patients (mean age: 38± 17.9, range 15–66 years; 5 males and 6 females; mean BCVA: 0.5 logMAR, range 0.0–1.1) from 5 independent families harboring a pathogenic heterozygous mutation in the OPA1 gene were included in the study. This evidence concerns the gene OPA1 and autosomal dominant optic atrophy.