PSEN1 and Alzheimer disease: A limited number of reports have included the NOR in APP/PS1dE9 transgenic mice in the early period of AD; several papers have illustrated that deficits existed in other transgenic mice related to Aβ at the age of 6–8 months [34], and another study demonstrated that APP/PS1 mice aged 8 months exhibited short-term memory deficits [28].