Intraperitoneal injection of TSA at a dose of 30 mg/kg obviously improved the PI of the APP/PS1 mice (p = 0.000), which was comparable to that of the WT control mice (p = 0.282) and indicated 30 mg/kg TSA (i.p.)rescued the dysfunction of short-term memory in the mice with AD. The gene discussed is APP; the disease is Alzheimer disease.