Increased EHD2 mRNA expression was significantly associated with extrathyroidal extension (p < 0.001), pT3-4 (p < 0.001), lymph node metastasis (p < 0.001), higher risk of recurrence (p < 0.001), BRAF V600E (p < 0.001), and BRAFV600E-like PTC (p < 0.001). Here, EHD2 is linked to metastasis.