Although the median antibody titer for Hcp1 was not significantly different between bacteremic and non-bacteremic patients (median 22,108, IQR 9,045–66,612 versus median 14,769, IQR 4,154–39,255, P < 0.057), the median antibody titer for OPS was higher in bacteremia patients compared to non-bacteremia patients (median 9,636, IQR 4,150–28,886 versus median 6389, IQR 1817–16106, P = 0.019) (Fig 4). Here, LRP5 is linked to bacterial infectious disease with sepsis.