IL-17, a proinflammatory cytokine produced by RA synovium [32], stimulates the macrophages’ production of IL-1 and TNF-a [34] and activates human synoviocytes to produce IL-6, IL-8, GM-CSF, and PGE2 [35, 36]. The gene discussed is CXCL8; the disease is rheumatoid arthritis.