Fibrosis is considered a wound healing reaction to injury, in which the balance between tissue repair and excessive ECM accumulation is changed towards the latter.15 Fibrogenesis is initiated by tissue injury, which triggers inflammation by recruiting pro-inflammatory factors.15 The NF-κB pathway is a key regulator of inflammatory response as its activation induces the transcription of pro-inflammatory mediators. The gene discussed is NFKB1; the disease is fibrosis.