The UPR and autophagy are known to be activated following cancer therapies, such as chemotherapy and radiotherapy, and protect cancer cells from ER stress-induced apoptotic cell death.50, 51, 52, 53 The marked suppression of IRE1 and PERK signaling of the UPR and UPR-induced autophagy by Yip1A knockdown provides evidence that targeting Yip1A has potential to overcome apoptosis resistance and to enhance the sensitivity of cancer cells to anticancer treatments. The gene discussed is EIF2AK3; the disease is cancer.