Loss of FOCAD plays a potential tumor suppressor role in breast cancer, colorectal cancer, and glioblastoma.30, 31, 32 Recently, miR-491-5p has been reported to be involved in several cancer types.10, 11, 12, 13 Until now, no reports have investigated the expression pattern, function, and underlying mechanisms of miR-491-5p in GC. The gene discussed is FOCAD; the disease is glioblastoma.