Furthermore, overexpression of Foxi1 decreased the expression levels of pro-caspase 3, BCL-2, CDK6, and CCND1, but increased the expression level of active caspase 3 and cleaved PARP (Figure 6m), suggesting that Foxi1 contributes to the proliferation inhibition, apoptosis promotion, and cell cycle arrest by modulating miR-491-5p transcription in GC cells. The gene discussed is CCND1; the disease is gastric cancer.