Foxi1 belongs to the forkhead-box (FOX) family of genes, which have been implicated in carcinogenesis through gene amplification, chromosomal translocation, retroviral integration, and transcriptional regulation.33 The FOXA1 gene is amplified and overexpressed in lung and esophageal cancer, and it is upregulated in pancreatic cancer and basal cell carcinoma. This evidence concerns the gene FOXI1 and esophageal cancer.