miRNAs function as tumor suppressors or oncogenes by directly targeting specific genes.15 On the basis of the literature reviews and gene target prediction databases, including TargetScan (http://www.targetscan.org/), miRanda (http://www.microrna.org/), and miRBASE (http://www.mirbase.org/), we hypothesized that Wnt3a may be a potential target of miR-491-5p. Here, WNT3A is linked to neoplasm.