LRG1 and colorectal cancer: Leucine-rich-alpha-2-glycoprotein1 (LRG1) is a new regulator of pathogenic angiogenesis and a novel oncogene-associated protein.11, 12 Reports showed that LRG1 has an important role in epithelial–mesenchymal transition and angiogenesis in colorectal cancer; and glioma cell invasion, migration and angiogenesis promotion in the damaged retina.11, 12, 13 Reports showed that LRG1 promotes angiogenesis by modulating endothelial transforming growth factor b1 (TGF-β) signaling.