VEGF in combination with another factor, which is overexpressed in HCC, angiopoitin 2 (ANGPT2) functions synergistically in vascular remodeling during angiogenesis,35 whereas angiopoitin 1 (ANGPT1) is involved in the maturation and stabilization of newly formed blood vessels. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.