As previous study shown, two signaling pathways of Akt/mTOR and Erk signaling pathway acted an important role in arginine depletion therapy for some tumors such as non-Hodgkin's lymphoma cells.33 In our research, after treatment with rhArg we detected that the expression of phosphorylation of Akt and mTOR was attenuated in a time- and dose-dependent manner in H1975 cells. The gene discussed is AKT1; the disease is non-Hodgkin lymphoma.