APP and major depressive disorder: EphB2 is one of the kinases, which could mediate tyrosine phosphorylation of GluN2B at Y1472 and stabilize NMDA receptors on the cell surface and thereby increase the response of NMDA receptors.17 Increasing EphB2 expression in the dorsal hippocampus of APP transgenic mice with lentiviral vector reversed the deficits in memory impairment and anxiety- or depression-like behaviors by recovering GluN2B-containing NMDA receptors trafficking.