FOXP3 and colitis: Moreover, GW9662 weakened the downregulation of Th17 cell-specific cytokine expression and the upregulation of IL-10 expression by madecassic acid in the colons (Figure 8d) and diminished madecassic acid-induced upregulation of Foxp3 expression (Figure 8b and Supplementary Figure S1) and protection against colitis (Figures 8e–h).