TRPM8 and migraine disorder: Antagonists of TRPM8 as therapeutics for chronic pain, migraine or inflammation have been pursued over the recent decade by many pharmaceutical companies such as Hydra Biosciences, Glenmark, Janssen, Pfizer, Bayer, Grunenthal, Mitsubishi Tanabe, RaQualia, Dompe/Axxam, BASF, Dendreon and Amgen.