Thus, reduced levels of mRNA encoding GAD67 in the DLPFC interneurons may be a primary component of disease process and might contribute to pre-and post-synaptic changes including the reduced expressions of PVALB and GAT1 and elevated expression of GABAA receptor α2 subunits in patients with schizophrenia [61,62]. This evidence concerns the gene SLC6A1 and schizophrenia.