The decreased dopamine signaling via the reduced expression levels of markers of dopamine axons, such as tyrosine hydroxylase, and dopamine transporter, reduced levels of glutamate-mediated excitation to midbrain dopamine and reduced availability of extracellular dopamine in the DLPLC may be associated with working memory impairments in patients with schizophrenia [63,64,65,66]. The gene discussed is TH; the disease is schizophrenia.