We recently discovered a 5-biomarker signatures, IL4R, AQA598, RSPO3, CHAD and UNQ9419 for AIH, by serological screening of patients with AIH and healthy donors (HD) on a protein microarray representing 1626 human proteins20, 22, and asked if any different marker combination had equal or higher performance. This evidence concerns the gene IL4R and autoimmune hepatitis.