CXCR3 and neoplasm: While melanoma engraftment correlated with increased monocyte/macrophage numbers in lungs, the numbers of monocytes in spleen did not differ with introduction of tumor in WT or CXCR3−/− mice (Supplemental Fig. 2A); a modest increase in macrophage numbers in spleen of WT, but not CXCR3−/− mice, was observed with introduction of tumor (Supplemental Fig. 2B).