On the other hand, the TCF4 variant rs784257 shows higher risk of FECD on men (OR=7.56, 95% CI=5.96, 9.57) than women (OR=5.06, 95% CI=4.29, 5.96, Phet=0.0063). Here, TCF4 is linked to Fuchs endothelial corneal dystrophy.