We also observed modest evidence for association at AGBL1 (P=7.5 × 10−5) and LOXHD1 (P=3.4 × 10−4), two of seven genes previously implicated in FECD through family-based and gene-targeted studies (Supplementary Table 4). Here, LOXHD1 is linked to Fuchs endothelial corneal dystrophy.