RAN and hepatocellular carcinoma: To verify whether SGK1 modulation affects the nuclear export of short non-coding RNAs (miRNAs) within the RAN:GTP:Exportin-5 complex44 by modulating the activity of the RAN/RANBP1 pathway10, 45, we first used qRT-PCR to examine the levels of 85 microRNAs involved in cancer in a hepatic carcinoma-derived HUH7 cell line treated with either SI113 or vehicle alone (DMSO).