Transgenic mice expressing a Myc-tagged ALS-linked Q331K mutant human TDP-43 at 1.2 times the normal level of TDP-43 throughout the central nervous system, including in motor neurons, oligodendrocytes and astrocytes, were previously shown to develop progressive adult-onset motor neuron disease [2]. The gene discussed is MYC; the disease is amyotrophic lateral sclerosis.