The functional interaction between MRX/MRNand Tel1/ATM is supported by the finding that biallelic mutation in theMRE11 gene causes a genetic syndrome, calledataxia-telangiectasia-like disease (ATLD), whose clinical phenotypes are nearlyindistinguishable from AT 90, 91. Here, ATM is linked to ataxia-telangiectasia-like disorder.