TNF and cancer: Clearly, more in-depth analysis will be needed to fully clarify the functionalsignificance of TNFα-MAP4K4 signaling for cancer cell progression (Fig. 1C).However, our study of host cell exploitation by an intracellular pathogen hasrevealed an interesting link between inflammatory cytokine signaling and cellmobilization, which may also be relevant in cancer metastasis and immune cellmobilization under conditions of chronic inflammation such as rheumatoidarthritis.