MAPT and Cognitive impairment: Interestingly, the conformation of a local peptidyl-prolylbond has also been identified in the regulation of Tau function, specifically proline232-directed control of phosphorylation at threonine 231.cis-phosphorylated Tau cannot promote microtubule assembly, is moreresistant to dephosphorylation and degradation, is prone to aggregation and isassociated with cognitive impairment in AD.