It is well known that superficial spreading melanoma (SSM) and nodular melanoma (NM) are associated with BRAF or NRAS mutations; acral lentiginous melanoma (ALM), lentigo maligna (LM), and mucosal melanoma are more often associated with KIT mutations; and ocular melanomas are not associated with these common oncogenes, but rather with GNAQ or GNA11 alterations1, 2. The gene discussed is NRAS; the disease is melanoma.