In line with the general perception that IFN-γ increases tumour immunogenicity,27 and with our own observation that recombinant IFN-γ had a striking effect on CSC-like cells (Figure 3), we saw an upregulation of MHC class I and CD54 expression on CSC-like cells upon exposure to supernatants of activated γδ T cells (Figure 5a). This evidence concerns the gene ICAM1 and neoplasm.