We have analysed ten polymorphisms in the OPG, RANKL and RANK genes in patients with CN, diabetic neuropathy (N) and diabetes without symptoms of neuropathy or CN (D) (blood samples were collected and analysed from 77 (CN), 77 (N) and 106 (D) patients). This evidence concerns the gene TNFRSF11B and cyclic hematopoiesis.