HJURP and neoplasm: We examined both cell lines by immunofluorescence following HJURP depletion and observed a striking enlargement of nucleus and micronucleus formation following HJURP depletion exclusively in the tumor-derived MCF7 cell line and not in the MCF10a cell line, suggesting an accumulation of aneuploidy (Fig. 6B; Supplemental Fig. S6B).