Furthermore, cluster 3 was associated with grade (p < 0.001; all except one tumor were of the highest grade), ER (p < 0.001; mostly negative), PR (p < 0.001; mostly negative) and TP53 status (p < 0.001; all except for two tumors were mutated) (Additional files 1e and 7). Here, TP53 is linked to neoplasm.