MUC1 and neoplasm: The putative tumor-suppressor miRNA miR-1226*, which was more highly expressed in COCA cluster 1 and for which overexpression resulted in both decreased proliferation, cell viability, ER and p-AKT levels, and increased apoptosis, has previously been found to target and downregulate expression of the MUC1 oncoprotein and induce cell death [49].