CD34 and myelodysplastic syndrome: In acute leukemia, Grosjean-Raillard and colleagues demonstrated that treatment with KU-59403 represses the antiapoptotic transcription factor nuclear factor-κB (NF-κB) pathway, which has been found to be constitutively activated in CD34+ myeloblasts of high-risk myelodysplastic syndrome (MDS) and AML patients and consequently, it induces cell death via apoptosis [70].