Over a century, immunology has been employed to treat malignant tumors, such as monoclonal antibody (mAb), bispecific antibody, tumor vaccine, immune checkpoint blockade, cytokine-induced killer (CIKs), tumor-infiltrating lymphocytes (TILs), and most recently chimeric antigen receptor T (CAR-T) [1]. This evidence concerns the gene TRAF3IP2 and neoplasm.