ITGAM and neoplasm: Finally, CD11 antigen-like family member B (CD11b)-positive, interferon gamma receptor 1 (Gr1)-negative, and cell surface glycoprotein F4/80-positive (CD11b+Gr1−F4/80+) tumor-associated macrophages trigger metastasis of breast cancer via activation of the epidermal growth factor receptor (EGFR) signaling pathway [44].