Endogenous miR-126 is down-regulated in primary breast cancer tissues [33] and can suppress endothelial cell recruitment, angiogenesis, and metastatic formation by modulating the expression of insulin-like growth factor-binding protein 2 (IGFBP2), C-Mer tyrosine kinase (MERTK), and phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) [34]. This evidence concerns the gene IGFBP2 and breast carcinoma.